John Wayne Casserole Recipe

Overhead shot of one serving of John Wayne Casserole on a white plate.

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John Wayne Casserole with Bisquick is a hearty ground beef casserole made with a biscuit base, seasoned beef, onion, bell pepper, tomatoes with green chiles, a creamy sour cream and mayo layer, and plenty of cheddar cheese. This easy John Wayne casserole recipe is perfect for a comforting family dinner.

Prep Time30

Cook Time40

Total Time1 10

Course: Main Course

Cuisine: American

Keyword: ground beef casserole with biscuit mix, john wayne casserole, john wayne casserole with bisquick

Servings: servings

Calories: 577kcal

Author: Mindy Boyd

Ingredients

For the filling:

2 pounds lean ground beef
1 cup onion
1 green bell pepper
1 can diced tomatoes with green chiles 10 ounces
2 packets taco seasoning 1 ounce each
nonstick cooking spray

For the biscuit base:

2 ¼ cups biscuit mix
1 cup milk

For the creamy topping:

½ cup sour cream
½ cup mayonnaise
1 cup shredded cheddar cheese

For the topping:

1 cup shredded cheddar cheese

Instructions

Preheat: Preheat the oven to 350°F and spray a 9X13-inch casserole dish with nonstick cooking spray.
nonstick cooking spray
Prep: Chop the onion and bell pepper and grate the cheese.
Make the topping: Combine the mayo, sour cream, and 1 cup of the cheese in a small bowl. Set aside.
½ cup sour cream, ½ cup mayonnaise, 1 cup shredded cheddar cheese
Cook the beef: Cook the ground beef, onion, and bell pepper in a large skillet over medium-high heat, stirring occasionally, until the beef is browned. Drain if not using lean ground beef. Add the taco seasoning and tomatoes and cook, stirring constantly, until combined and heated through.
2 pounds lean ground beef, 1 cup onion, 1 green bell pepper, 1 can diced tomatoes with green chiles, 2 packets taco seasoning
Make the biscuit base: In a medium bowl, combine the biscuit mix and milk, mixing just until combined. Press evenly into the bottom of the prepared casserole dish.
2 ¼ cups biscuit mix, 1 cup milk
Assemble the casserole: Spread the beef mixture over the biscuit base, then top with the sour cream mixture and 1 cup shredded cheddar cheese.
1 cup shredded cheddar cheese
Bake: Bake for 30–35 minutes, or until hot and bubbly.

Notes

Spray a rubber spatula with nonstick cooking spray to make it easier to press the sticky biscuit mixture evenly into the casserole dish.

If you're not using lean ground beef, drain the excess fat before adding the remaining filling ingredients.

Don't add the water called for on the taco seasoning packet. The liquid from the canned tomatoes with green chiles provides plenty of moisture.

Nutrition information is approximate and will vary based on the specific ingredients and brands used.

Nutrition